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Science 5 April 1996:
Vol. 272. no. 5258, pp. 46 - 0
DOI: 10.1126/science.272.5258.46
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Perspectives

Roger I. Glass, Jon R. Gentsch, Bernard Ivanoff

Rotavirus infects nearly all humans early in their lives and can sometimes prove dangerous or fatal. In his Perspective, Glass recounts the successes of first and second generation vaccines against rotaviruses. Nevertheless he believes that two papers in this week's issue [Ball et al. (p. 101) and Burns et al. (p. 104)] illuminate aspects of the virulence of rotavirus and its susceptibility to immune attack that may guide the development of an even more effective third generation vaccine.

R. I. Glass and J. R. Gentsch are in the Gastroenteritis Section, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. B. Ivanoff is in the Vaccine Research and Development Division, Global Programme on Vaccines, World Health Organization, Geneva, Switzerland. R. I. Glass is currently on assignment to the Global Programme on Vaccines and Immunizations, World Health Organization, Geneva 27, Switzerland, CH-1211. E-mail: glassr@who.ch


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Epidemiology of Rotavirus Diarrhea among Children in Saudi Arabia: First Detection of G9 and G12 Strains.
A. M. Kheyami, T. Nakagomi, O. Nakagomi, W. Dove, C. A. Hart, and N. A. Cunliffe (2008)
J. Clin. Microbiol. 46, 1185-1191
   Abstract »    Full Text »    PDF »
Protein Kinase R Mediates Intestinal Epithelial Gene Remodeling in Response to Double-Stranded RNA and Live Rotavirus.
M. Vijay-Kumar, J. R. Gentsch, W. J. Kaiser, N. Borregaard, M. K. Offermann, A. S. Neish, and A. T. Gewirtz (2005)
J. Immunol. 174, 6322-6331
   Abstract »    Full Text »    PDF »
Increased Enterocyte Production in Gnotobiotic Rats Mono-Associated with Lactobacillus rhamnosus GG.
M. Banasaz, E. Norin, R. Holma, and T. Midtvedt (2002)
Appl. Envir. Microbiol. 68, 3031-3034
   Abstract »    Full Text »    PDF »
Gene Expression Pattern in Caco-2 Cells following Rotavirus Infection.
M. A. Cuadras, D. A. Feigelstock, S. An, and H. B. Greenberg (2002)
J. Virol. 76, 4467-4482
   Abstract »    Full Text »    PDF »
Food Supplementation with Milk Fermented by Lactobacillus casei DN-114 001 Protects Suckling Rats from Rotavirus-Associated Diarrhea.
C. Guérin-Danan, J.-C. Meslin, A. Chambard, A. Charpilienne, P. Relano, C. Bouley, J. Cohen, and C. Andrieux (2001)
J. Nutr. 131, 111-117
   Abstract »    Full Text »
Malnutrition Modifies Pig Small Intestinal Inflammatory Responses to Rotavirus.
R. T. Zijlstra, B. A. McCracken, J. Odle, S. M. Donovan, H. B. Gelberg, B. W. Petschow, F. A. Zuckermann, and H. R. Gaskins (1999)
J. Nutr. 129, 838-843
   Abstract »    Full Text »
Development of a Heterologous Model in Germfree Suckling Rats for Studies of Rotavirus Diarrhea.
C. Guerin-Danan, J. C. Meslin, F. Lambre, A. Charpilienne, M. Serezat, C. Bouley, J. Cohen, and C. Andrieux (1998)
J. Virol. 72, 9298-9302
   Abstract »    Full Text »    PDF »
Protective Immunity Induced by Oral Immunization with a Rotavirus DNA Vaccine Encapsulated in Microparticles.
S. C. Chen, D. H. Jones, E. F. Fynan, G. H. Farrar, J. C. S. Clegg, H. B. Greenberg, and J. E. Herrmann (1998)
J. Virol. 72, 5757-5761
   Abstract »    Full Text »    PDF »
Cleavage of Rhesus Rotavirus VP4 after Arginine 247 Is Essential for Rotavirus-Like Particle-Induced Fusion from Without.
J. M. Gilbert and H. B. Greenberg (1998)
J. Virol. 72, 5323-5327
   Abstract »    Full Text »    PDF »


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