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Science 15 December 1995:
Vol. 270. no. 5243, p. 1751
DOI: 10.1126/science.270.5243.1751
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News & Comment

Eliot Marshall

A tough review of the state of the art in gene therapy has concluded that the technology has been oversold, there are few unambiguous examples in which patients have benefited from the technique, and the National Institutes of Health has supported too many clinical trials that are of limited scientific value. The bottom line: More research is needed to improve basic gene transfer techniques. (Report is available from the World Wide Web at <http://www.nih.gov/news/panelrep.html>).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
RAC Oversight of Gene Transfer Research: A Model Worth Extending?.
N. M. P. King (2002)
J. Law Med. Ethics 30, 381-389
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The Immune Response to Ocular Herpes Simplex Virus Type 1 Infection.
D. J.J. Carr, P. Härle, and B. M. Gebhardt (2001)
Experimental Biology and Medicine 226, 353-366
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Gene therapy in hereditary retinal degeneration and the tower of Babel.
U PLEYER (2001)
Br J Ophthalmol 85, 255-256
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Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model.
M. Andang, J. Hinkula, G. Hotchkiss, S. Larsson, S. Britton, F. Wong-Staal, B. Wahren, and L. Ahrlund-Richter (1999)
PNAS 96, 12749-12753
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Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery.
I. van der Woude, A. Wagenaar, A. A. P. Meekel, M. B. A. ter Beest, M. H. J. Ruiters, J. B. F. N. Engberts, and D. Hoekstra (1997)
PNAS 94, 1160-1165
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Medical Genetics.
E. R. B. McCabe (1996)
JAMA 275, 1819-1821
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