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Science 15 December 1995:
Vol. 270. no. 5243, p. 1737
DOI:

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The aldol condensation couples a ketone to an aldehyde and is one of the most basic carbon-carbon bond-forming reactions in organic chemistry. Many methods exist to facilitate this reaction, but they often require stoichiometric reagents and the use of protective groups. Wagner et al. (p. 1797) have generated catalytic antibodies based on class I aldolases that can couple a wide variety of aldehydes and ketones through this reaction. These antibodies were generated by immunization with a reactive compound, a method detailed in a Research Article by Wirsching et al. (p. 1775).




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Science. ISSN 0036-8075 (print), 1095-9203 (online)