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Science 20 October 1995:
Vol. 270. no. 5235, pp. 368 - 369
DOI: 10.1126/science.270.5235.368
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News

Rachel Nowak

Geneticists can now identify about half the estimated 100,000 genes in the human genome, but they don't have a clue about what most of them actually do. Now, two new techniques described in this issue of Science could transform research on gene function. They offer two different ways of detecting the expression of hundreds or thousands of genes at a time, thereby allowing researchers to determine which genes are turned on in particular tissues, and at what levels. And that provides a quick way of assessing how gene expression patterns change during development, disease, and other physiological conditions.


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HOX Pro: a specialized database for clusters and networks of homeobox genes.
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Microelectrophoretic Analysis of Changes in Protein Expression Patterns in Mouse Oocytes and Preimplantation Embryos.
R. Sasaki, T. Nakayama, and T. Kato (1999)
Biol Reprod 60, 1410-1418
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Vascular Endothelial Genes That Are Responsive to Tumor Necrosis Factor-{alpha} In Vitro Are Expressed in Atherosclerotic Lesions, Including Inhibitor of Apoptosis Protein-1, Stannin, and Two Novel Genes.
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Paradoxical Preservation of a Lipopolysaccharide Response in C3H/HeJ Macrophages: Induction of Matrix Metalloproteinase-9.
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J. Immunol. 162, 3596-3600
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The Significance of Digital Gene Expression Profiles.
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