Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Originally published in Science Express on 12 March 2009
Science 17 April 2009:
Vol. 324. no. 5925, pp. 392 - 397
DOI: 10.1126/science.1170540
Prev | Table of Contents | Next

Reports

In Vivo Analysis of Dendritic Cell Development and Homeostasis

Kang Liu,1* Gabriel D. Victora,1{dagger} Tanja A. Schwickert,1{dagger} Pierre Guermonprez,1 Matthew M. Meredith,1 Kaihui Yao,1 Fei-Fan Chu,1 Gwendalyn J. Randolph,2 Alexander Y. Rudensky,3,4 Michel Nussenzweig1,4*

Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC and monocyte lineage commitment occurs and the nature of the DC precursor that migrates from the bone marrow to peripheral lymphoid organs are unknown. We show that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs (cDCs), but not monocytes, and finally to committed precursors of cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through and migrate along high endothelial venules and later disperse and integrate into the DC network. Further cDC development involves cell division, which is controlled in part by regulatory T cells and fms-like tyrosine kinase receptor-3.

1 Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.
2 Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
3 Department of Immunology and Howard Hughes Medical Institute (HHMI), University of Washington, Seattle, WA 98195, USA.
4 HHMI, Rockefeller University, New York, NY 10021, USA.

{dagger} These authors contributed equally to this work.

* To whom correspondence should be addressed. E-mail: liuk{at}rockefeller.edu (L.K.); nussen{at}rockefeller.edu (M.N.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.
L. Chorro, A. Sarde, M. Li, K. J. Woollard, P. Chambon, B. Malissen, A. Kissenpfennig, J.-B. Barbaroux, R. Groves, and F. Geissmann (2009)
J. Exp. Med.
   Abstract »    Full Text »    PDF »
Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop.
K. Hochweller, T. Miloud, J. Striegler, S. Naik, G. J. Hammerling, and N. Garbi (2009)
Blood 114, 4411-4421
   Abstract »    Full Text »    PDF »
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.
G. Darrasse-Jeze, S. Deroubaix, H. Mouquet, G. D. Victora, T. Eisenreich, K.-h. Yao, R. F. Masilamani, M. L. Dustin, A. Rudensky, K. Liu, et al. (2009)
J. Exp. Med. 206, 1853-1862
   Abstract »    Full Text »    PDF »
Cutting Edge: B220+CCR9- Dendritic Cells Are Not Plasmacytoid Dendritic Cells but Are Precursors of Conventional Dendritic Cells.
E. Segura, J. Wong, and J. A. Villadangos (2009)
J. Immunol. 183, 1514-1517
   Abstract »    Full Text »    PDF »
Selective Expansion of the Monocytic Lineage Directed by Bacterial Infection.
N. V. Serbina, T. M. Hohl, M. Cherny, and E. G. Pamer (2009)
J. Immunol. 183, 1900-1910
   Abstract »    Full Text »    PDF »
The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis.
D. Kingston, M. A. Schmid, N. Onai, A. Obata-Onai, D. Baumjohann, and M. G. Manz (2009)
Blood 114, 835-843
   Abstract »    Full Text »    PDF »
Dendritic cell homeostasis.
M. Merad and M. G. Manz (2009)
Blood 113, 3418-3427
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)