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Science 10 April 2009:
Vol. 324. no. 5924, pp. 275 - 279
DOI: 10.1126/science.324.5924.275

From the AAAS Office of Publishing and Member Services

BUSINESS OFFICE FEATURE:
Life Science Technologies: Sanger Who? Sequencing the Next Generation

Jeffrey M. Perkel

In November 2008 Elaine Mardis of Washington University in St. Louis and colleagues published the complete genome sequence of an individual with acute myeloid leukemia. Coming just a few years after the decade-long, multibillion dollar Human Genome Project, the paper was remarkable on several levels. For one thing, the team sequenced two human genomes, both cancerous and normal, some 140 billion bases in all. More impressive, though, was what the study omitted: the 50 human genomes Mardis sequenced that year (albeit not as deeply) for the 1,000 Genomes Project. "It's like a whole new world," she says. Welcome to the sequencing frontier.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)