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Science 13 March 2009:
Vol. 323. no. 5920, p. 1429
DOI: 10.1126/science.1155917
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Technical Comments

Response to Comment on "Detection, Stimulation, and Inhibition of Neuronal Signals with High-Density Nanowire Transistor Arrays"

Brian P. Timko,1 Fernando Patolsky,2 Charles M. Lieber1,3*

Fromherz and Voelker make incorrect assumptions about our experiments that raise serious questions about the validity of their claims. We show that our calibrated signals are consistent with previously published data and a general model with biophysically relevant parameters. Additionally, the wide variation in previously published signal amplitudes suggests caution in applying and drawing conclusions from the models of Fromherz and Voelker.

1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
2 School of Chemistry, Tel Aviv University, Tel Aviv 69978, Israel.
3 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

* To whom correspondence should be addressed. E-mail: cml{at}cmliris.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)