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Originally published in Science Express on 19 February 2009
Science 6 March 2009:
Vol. 323. no. 5919, pp. 1360 - 1363
DOI: 10.1126/science.1166453
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Reports

A Putative ABC Transporter Confers Durable Resistance to Multiple Fungal Pathogens in Wheat

Simon G. Krattinger,1* Evans S. Lagudah,2*{dagger} Wolfgang Spielmeyer,2 Ravi P. Singh,3 Julio Huerta-Espino,4 Helen McFadden,2{ddagger} Eligio Bossolini,1§ Liselotte L. Selter,1 Beat Keller1{dagger}

Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate–binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.

1 Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland.
2 Commonwealth Scientific and Industrial Research Organisation (CSIRO) Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia.
3 International Maize and Wheat Improvement Center (CIMMYT), Apdo. Postal 6-641, 06600 Mexico DF, Mexico.
4 Campo Experimental Valle de Mexico INIFAP, Apdo. Postal 10, 56230 Chapingo, Edo de Mexico, Mexico.

* These authors contributed equally to this work.

{ddagger} Present address: Science and Research Division, Department of Innovation, Industry, Science and Research, Industry House Level 6, 10 Binara Street, Canberra, ACT, 2601, Australia.

§ Present address: Institute of Plant Sciences, University of Bern, 3013 Bern, Switzerland.

{dagger} To whom correspondence should be addressed. E-mail: evans.lagudah{at}csiro.au (E.S.L.), bkeller{at}botinst.uzh.ch (B.K.)

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A Kinase-START Gene Confers Temperature-Dependent Resistance to Wheat Stripe Rust.
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