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Science 20 February 2009:
Vol. 323. no. 5917, pp. 1080 - 1083
DOI: 10.1126/science.323.5917.1080
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From the AAAS Office of Publishing and Member Services

Preparing The Proteome For Mass Spectrometry

Gautam Thor

Preparing samples for mass spectrometry analysis is not as simple as merely isolating total protein from its biological source. They also need to be in a chemical environment that is MS friendly and allows their interrogation. Often enzymatic digestion and/or depletion/partitioning/enrichment are required to obtain a usable sample; but what are the best sample preparation methods, and how might they impact experiments?




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Science. ISSN 0036-8075 (print), 1095-9203 (online)