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Science 16 January 2009:
Vol. 323. no. 5912, pp. 347 - 348
DOI: 10.1126/science.1169408
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Perspectives

MOLECULAR BIOLOGY:
The Structure of Change

Colin A. M. Semple1 and Martin S. Taylor2

The organization of DNA and proteins into chromatin influences the location and rates of mutations across eukaryotic genomes.

1MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK. E-mail: colins{at}hgu.mrc.ac.uk

2European Molecular Biology Laboratory European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. E-mail: mst{at}ebi.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)