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Science 5 December 2008:
Vol. 322. no. 5907, pp. 1483 - 1484
DOI: 10.1126/science.1167571
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Perspectives

CELL SIGNALING:
Fat Stress and Liver Resistance

Wataru Ogawa1 and Masato Kasuga1,2

Communication among immune and fat cells in adipose tissue and liver hepatocytes underlies the pathogenesis of obesity-related insulin resistance.

1Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

2Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan. E-mail: kasuga{at}med.kobe-u.ac.jp

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Science. ISSN 0036-8075 (print), 1095-9203 (online)