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Science 7 November 2008:
Vol. 322. no. 5903, pp. 872 - 873
DOI: 10.1126/science.1166845
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Perspectives

CELL BIOLOGY:
Going Global on Ubiquitin

Caroline Grabbe1 and Ivan Dikic1,2,3

A new technique that profiles protein stability provides a powerful platform in which high-throughput screening can be performed in real time with single-cell resolution.

1Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Frankfurt am Main, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany.

2Mediterranean Institute for Life Sciences, 21000 Split, Croatia.

3Department of Immunology, School of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia. E-mail: ivan.dikic{at}biochem2.de

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Science. ISSN 0036-8075 (print), 1095-9203 (online)