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Science 31 October 2008:
Vol. 322. no. 5902, p. 675
DOI: 10.1126/science.1161387
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Technical Comments

Response to Comment on "Differential Rescue of Light- and Food-Entrainable Circadian Rhythms"

Patrick M. Fuller, Jun Lu, Clifford B. Saper*

The points raised by Mistlberger et al. arise from a shortcoming in their approach, namely, that they measure the response to food restriction by using food-seeking behavior, which is confounded by homeostatic inputs. We used unrelated circadian-driven physiological responses, and we stand by our finding that the dorsomedial nucleus of the hypothalamus contains a food-entrainable oscillator that is sufficient for entrainment of circadian rhythms of body temperature and locomotor activity.

Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

* To whom correspondence should be addressed. E-mail: csaper{at}bidmc.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)