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Science 10 October 2008:
Vol. 322. no. 5899, pp. 210 - 213
DOI: 10.1126/science.322.5899.210
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Spiraling Costs Threaten Gridlock

David Malakoff

The gold standard of medical science--the big randomized trial--is in danger of being priced out of reach by technical complexity, poor management, and paperwork.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)