Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 August 2008:
Vol. 321. no. 5890, pp. 824 - 826
DOI: 10.1126/science.1157312
Prev | Table of Contents | Next

Reports

Programming DNA Tube Circumferences

Peng Yin,1,2,3{dagger} Rizal F. Hariadi,4 Sudheer Sahu,6 Harry M. T. Choi,2 Sung Ha Park,1,5* Thomas H. LaBean,6,7 John H. Reif6

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

1 Department of Computer Science, California Institute of Technology, Pasadena, CA 91125, USA.
2 Department of Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA.
3 Center for Biological Circuit Design, California Institute of Technology, Pasadena, CA 91125, USA.
4 Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA.
5 Center for the Physics of Information, California Institute of Technology, Pasadena, CA 91125, USA.
6 Department of Computer Science, Duke University, Durham, NC 27708, USA.
7 Department of Chemistry, Duke University, Durham, NC 27708, USA.

* Present address: Department of Physics, SKKU Advanced Institute of Nanotechnology, Sungkyunkwan University, Suwon, 440-746, Korea.

{dagger} To whom correspondence should be addressed. E-mail: py{at}caltech.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Folding DNA into Twisted and Curved Nanoscale Shapes.
H. Dietz, S. M. Douglas, and W. M. Shih (2009)
Science 325, 725-730
   Abstract »    Full Text »    PDF »
A partition function algorithm for interacting nucleic acid strands.
H. Chitsaz, R. Salari, S. C. Sahinalp, and R. Backofen (2009)
Bioinformatics 25, i365-i373
   Abstract »    Full Text »    PDF »
Control of Self-Assembly of DNA Tubules Through Integration of Gold Nanoparticles.
J. Sharma, R. Chhabra, A. Cheng, J. Brownell, Y. Liu, and H. Yan (2009)
Science 323, 112-116
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)