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Science 18 July 2008:
Vol. 321. no. 5887, pp. 411 - 413
DOI: 10.1126/science.1159519
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Reports
Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP
N. Sudarsan,1
E. R. Lee,2
Z. Weinberg,2
R. H. Moy,3
J. N. Kim,2
K. H. Link,1
R. R. Breaker1,2,3*
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.
2 Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
3 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
* To whom correspondence should be addressed. E-mail: ronald.breaker{at}yale.edu
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