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Science 18 July 2008:
Vol. 321. no. 5887, p. 342
DOI: 10.1126/science.1158766
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Technical Comments

Comment on "A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea"

Thijs J. G. Ettema* and Siv G. E. Andersson

Berg et al. (Reports, 14 December 2007, p. 1782) reported the discovery of an autotrophic carbon dioxide–fixation pathway in Archaea and implicated a substantial role of this pathway in global carbon cycling based on sequence analysis of Global Ocean Sampling data. We question the validity of the latter claim.

Department of Molecular Evolution, Evolutionary Biology Centre, Uppsala University, Uppsala, S-752 36 Sweden.

* To whom correspondence should be addressed. E-mail: thijs.ettema{at}ebc.uu.se

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Science. ISSN 0036-8075 (print), 1095-9203 (online)