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Science 11 July 2008:
Vol. 321. no. 5886, p. 200
DOI: 10.1126/science.1156079
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Technical Comments

Response to Comment on "Genetically Determined Differences in Learning from Errors"

Tilmann A. Klein,1* Martin Reuter,2 D. Yves von Cramon,1,3 Markus Ullsperger1,3*

Since the publication of our findings, further genetic and pharmacological studies have bolstered our conclusion that dopamine D2 receptors are essential for performance monitoring and learning. Although the functionally complex dopamine D2 receptor gene polymorphism DRD2-TAQ-IA may also affect cellular signaling components, the accumulated evidence supports the notion that our findings were mediated by differential D2 receptor density.

1 Department of Cognitive Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04103, Germany.
2 Department of Psychology, University of Bonn, Bonn 53117, Germany.
3 Max Planck Institute for Neurological Research, Cologne 50931, Germany.

* To whom correspondence should be addressed. E-mail: tklein{at}cbs.mpg.de (T.A.K.); ullsperger{at}nf.mpg.de (M.U.)

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Science. ISSN 0036-8075 (print), 1095-9203 (online)