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Science 11 July 2008:
Vol. 321. no. 5886, p. 200
DOI: 10.1126/science.1155372
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Technical Comments

Comment on "Genetically Determined Differences in Learning from Errors"

Michael Lucht1* and Dieter Rosskopf2

Klein et al. (Reports, 7 December 2007, p. 1642) used individuals with a polymorphism adjacent to the dopamine receptor 2 gene as naturally occurring models for reduced brain dopamine receptor density in a probabilistic learning task. We raise the concern that this polymorphism resides in the gene for the kinase ANKK1, where it causes a nonconservative amino acid exchange.

1 Hospital for Psychiatry and Psychotherapy, Haus 30, Ernst-Moritz-Arndt University, Greifswald, Stralsund 18437, Germany.
2 Institute for Pharmacology, Ernst-Moritz-Arndt University, Greifswald, Greifswald 17487, Germany.

* To whom correspondence should be addressed. E-mail: lucht{at}uni-greifswald.de

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Science. ISSN 0036-8075 (print), 1095-9203 (online)