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Science 28 March 2008:
Vol. 319. no. 5871, pp. 1853 - 1855
DOI: 10.1126/science.319.5871.1853
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From the AAAS Office of Publishing and Member Services

BUSINESS OFFICE FEATURE:
Life Science Technologies: Genomic Biomarker Discovery: Bringing the Genome to Life

Jeffrey M. Perkel

A convergence of technological breakthroughs has taken genomic biomarker discovery to a new level. Between advances in sequencing, evolving array designs, and a more sophisticated understanding of genome architecture, simple tests for glucose, cholesterol, and human chorionic gonadotropin could soon be competing for pharmacy shelf space with gene expression– and epigenome-based diagnostics that promise to detect diseases earlier, stratify patients into treatment classes, and identify those most likely to respond to therapies. First to benefit: cancer patients. The era of personalized medicine is just around the corner.




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