Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II
Leighton J. Core and
John T. Lis*
Recent work has shown that the RNA polymerase II enzyme pausesat a promoter-proximal site of many genes in Drosophila andmammals. This rate-limiting step occurs after recruitment andinitiation of RNA polymerase II at a gene promoter. This stagein early elongation appears to be an important and broadly usedtarget of gene regulation.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
* To whom correspondence should be addressed. E-mail: jtl10{at}cornell.edu
DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1{alpha} gene locus.
L. Baranello, D. Bertozzi, M. V. Fogli, Y. Pommier, and G. Capranico (2009)
Nucleic Acids Res.
|Abstract »|Full Text »|PDF »
Establishing legitimacy and function in the new transcriptome.
H. van Bakel and T. R. Hughes (2009)
Brief Funct Genomic Proteomic
8, 424-436
|Abstract »|Full Text »|PDF »
Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5.
R. D. Meyer, E. V. Laz, T. Su, and D. J. Waxman (2009)
Mol. Endocrinol.
23, 1914-1926
|Abstract »|Full Text »|PDF »
A wave of nascent transcription on activated human genes.
Y. Wada, Y. Ohta, M. Xu, S. Tsutsumi, T. Minami, K. Inoue, D. Komura, J. Kitakami, N. Oshida, A. Papantonis, et al. (2009)
PNAS
106, 18357-18361
|Abstract »|Full Text »|PDF »
TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II.
K. Glover-Cutter, S. Larochelle, B. Erickson, C. Zhang, K. Shokat, R. P. Fisher, and D. L. Bentley (2009)
Mol. Cell. Biol.
29, 5455-5464
|Abstract »|Full Text »|PDF »
Chromatin poises miRNA- and protein-coding genes for expression.
A. Barski, R. Jothi, S. Cuddapah, K. Cui, T.-Y. Roh, D. E. Schones, and K. Zhao (2009)
Genome Res.
19, 1742-1751
|Abstract »|Full Text »|PDF »
Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome.
S. W. Hong, S. M. Hong, J. W. Yoo, Y. C. Lee, S. Kim, J. T. Lis, and D.-k. Lee (2009)
PNAS
106, 14276-14280
|Abstract »|Full Text »|PDF »
Induction of HoxB Transcription by Retinoic Acid Requires Actin Polymerization.
C. Ferrai, G. Naum-Ongania, E. Longobardi, M. Palazzolo, A. Disanza, V. M. Diaz, M. P. Crippa, G. Scita, and F. Blasi (2009)
Mol. Biol. Cell
20, 3543-3551
|Abstract »|Full Text »|PDF »
Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II.
C. Hodges, L. Bintu, L. Lubkowska, M. Kashlev, and C. Bustamante (2009)
Science
325, 626-628
|Abstract »|Full Text »|PDF »
Paused Pol II captures enhancer activity and acts as a potent insulator.
7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.
M. Barboric, T. Lenasi, H. Chen, E. B. Johansen, S. Guo, and B. M. Peterlin (2009)
PNAS
106, 7798-7803
|Abstract »|Full Text »|PDF »
Complexity in Transcription Control at the Activation Domain-Mediator Interface.
M. A. Balamotis, M. A. Pennella, J. L. Stevens, B. Wasylyk, A. S. Belmont, and A. J. Berk (2009)
Science Signaling
2, ra20
|Abstract »|Full Text »|PDF »
Postrecruitment Regulation of RNA Polymerase II Directs Rapid Signaling Responses at the Promoters of Estrogen Target Genes.
M. Kininis, G. D. Isaacs, L. J. Core, N. Hah, and W. L. Kraus (2009)
Mol. Cell. Biol.
29, 1123-1133
|Abstract »|Full Text »|PDF »
A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome.