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Reactivated memory undergoes a rebuilding process that dependson de novo protein synthesis. This suggests that retrieval isdynamic and serves to incorporate new information into preexistingmemories. However, little is known about whether or not proteindegradation is involved in the reorganization of retrieved memory.We found that postsynaptic proteins were degraded in the hippocampusby polyubiquitination after retrieval of contextual fear memory.Moreover, the infusion of proteasome inhibitor into the CA1region immediately after retrieval prevented anisomycin-inducedmemory impairment, as well as the extinction of fear memory.This suggests that ubiquitin- and proteasome-dependent proteindegradation underlies destabilization processes after fear memoryretrieval. It also provides strong evidence for the existenceof reorganization processes whereby preexisting memory is disruptedby protein degradation, and updated memory is reconsolidatedby protein synthesis.
National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
* To whom correspondence should be addressed. E-mail: kaang{at}snu.ac.kr
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