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Science 29 February 2008:
Vol. 319. no. 5867, pp. 1195 - 1196
DOI: 10.1126/science.1155093
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Perspectives

CHEMISTRY:
An Enlightening Structure-Function Relationship

Bruce A. Armitage1 Peter B. Berget2

Mutation and structural data elucidate distinct mechanisms by which different antibodies bind and induce luminescence of dye molecules.

1Department of Chemistry and Molecular Biosensor and Imaging Center (MBIC), Carnegie Mellon University, Pittsburgh, PA 15213, USA. E-mail: army{at}cmu.edu

2Department of Biological Sciences and MBIC, Carnegie Mellon University, Pittsburgh, PA 15213, USA. E-mail: berget{at}cmu.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)