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Science 16 November 2007:
Vol. 318. no. 5853, p. 1033
DOI: 10.1126/science.318.5853.1033n
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Long-term memory formation is known to depend on circadian rhythms, but the mechanisms involved remain to be elucidated. Rawashdeh et al. (p. 1144) asked whether the circadian system plays a regulatory role in memory formation in a diurnal vertebrate. Learning of a simple active-avoidance conditioning task in zebrafish was substantially better during the day than at night. This difference was largely the result of the effects of the circadian clock, with the effect on memory formation being mediated by pineal melatonin.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)