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Science 12 October 2007:
Vol. 318. no. 5848, p. 196
DOI: 10.1126/science.1146519
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Response to Comment on "Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment"

Gerald H. Jacobs1* and Jeremy Nathans2

Makous suggests that the novel color vision documented in knock-in mice neither requires visual system plasticity nor implies the emergence of a new dimension of sensory experience. We explain why we disagree.

1 Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara, CA 93106, USA.
2 Departments of Neuroscience, Ophthalmology, Molecular Biology and Genetics, and the Howard Hughes Medical Institute, Johns Hopkins Medical School, Baltimore, MD 21205, USA.

* To whom correspondence should be addressed. E-mail: jacobs{at}psych.ucsb.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)