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Science 12 October 2007: Vol. 318. no. 5848, p. 194 DOI: 10.1126/science.318.5848.194a
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Letters
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Technical Comment Abstracts
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COMMENT ON "Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment"
Walter Makous
Abstract: Jacobs et al. (Reports, 23 March 2007, p. 1723) reported that plasticity in the mammalian visual system permitted the emergence of "a new dimension of sensory experience" in mice genetically engineered to express a human longwavelength-sensitive cone photopigment. However, neither neural plasticity nor a new dimension of sensory experience is required to explain their results.
Full text at www.sciencemag.org/cgi/content/full/318/5848/196b
RESPONSE TO COMMENT ON "Emergence of Novel Color Vision in Mice Engineered to Express a Human Cone Photopigment"
Gerald H. Jacobs and Jeremy Nathans
Abstract: Makous suggests that the novel color vision documented in knock-in mice neither requires visual system plasticity nor implies the emergence of a new dimension of sensory experience. We explain why we disagree.
Full text at www.sciencemag.org/cgi/content/full/318/5848/196c
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Science. ISSN 0036-8075 (print), 1095-9203 (online)