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Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"
William F. Forrest1 and
Guy Cavet2*
Sjöblom et al. (Research Articles, 13 October 2006, p.268) used data from cancer genome resequencing to identify geneswith elevated mutation rates. Their analysis used point probabilitieswhen it should have used P values for the hypotheses they intendedto test. Reimplementing their analysis method with exact P valuesresults in far fewer genes with mutation rates that achievestatistical significance.
1 Department of Biostatistics, Genentech, Inc., South San Francisco, CA 94080, USA. 2 Department of Bioinformatics, Genentech, Inc., South San Francisco, CA 94080, USA.
* To whom correspondence should be addressed. E-mail: cavet.guy{at}gene.com
The editors suggest the following Related Resources on Science sites:
In Science Magazine
TECHNICAL COMMENTS
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RESEARCH ARTICLES
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