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Science 31 August 2007:
Vol. 317. no. 5842, pp. 1179 - 1180
DOI: 10.1126/science.1148530

Perspectives

MOLECULAR BIOLOGY:
miRNAs in Neurodegeneration

Sébastien S. Hébert and Bart De Strooper

Noncoding microRNAs are necessary for the survival of postmitotic cells such as neurons that die in Parkinson's and other brain diseases.


The authors are in the Center for Human Genetics, VIB and KULeuven, Herestraat 49, Leuven, Belgium. E-mail: bart.destrooper{at}med.kuleuven.be

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/{beta}-secretase expression.
S. S. Hebert, K. Horre, L. Nicolai, A. S. Papadopoulou, W. Mandemakers, A. N. Silahtaroglu, S. Kauppinen, A. Delacourte, and B. De Strooper (2008)
PNAS 105, 6415-6420
   Abstract »    Full Text »    PDF »
Conditional Loss of Dicer Disrupts Cellular and Tissue Morphogenesis in the Cortex and Hippocampus.
T. H. Davis, T. L. Cuellar, S. M. Koch, A. J. Barker, B. D. Harfe, M. T. McManus, and E. M. Ullian (2008)
J. Neurosci. 28, 4322-4330
   Abstract »    Full Text »    PDF »
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of {beta}-Site Amyloid Precursor Protein-Cleaving Enzyme 1.
W.-X. Wang, B. W. Rajeev, A. J. Stromberg, N. Ren, G. Tang, Q. Huang, I. Rigoutsos, and P. T. Nelson (2008)
J. Neurosci. 28, 1213-1223
   Abstract »    Full Text »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)