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Science 24 August 2007:
Vol. 317. no. 5841, pp. 1101 - 1106
DOI: 10.1126/science.317.5841.1101
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From the AAAS Office of Publishing and Member Services

BUSINESS OFFICE FEATURE:
Microarray Technologies: Bench to Bedside

Emma Hitt

DNA microarray technology has matured to the point where some applications are deemed reliable enough for use in patient care. At the same time, microarrays are evolving to help expand the understanding of transcriptome complexity: single nucleotide polymorphisms, copy number variation, CpG methylations, microRNAs–so many genetic and epigenetic variations and a slew of microarrays to investigate each one. Furthermore, newer DNA sequencing technologies now threaten to do to microarray technology what automobiles did to the horse and buggy. For now, however, the two approaches appear to coexist happily, and microarrays remain a perfectly reasonable way to get around the genome.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)