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Science 24 August 2007:
Vol. 317. no. 5841, p. 1036
DOI: 10.1126/science.1143658
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Technical Comments

Response to Comments by Timpson et al. and Yu et al.

Nitzan Mekel-Bobrov1,2 and Bruce T. Lahn1*

The lack of association of the abnormal spindle-like microcephaly associated (ASPM) and Microcephalin (MCPH1) genes with brain size or intelligence described by Timpson et al. has been reported previously, including by our own group. Moreover, as in most studies of selection, our analyses were entirely independent of phenotypic association. We also respond to the previously published comment by Yu et al., which argued that ASPM has not undergone positive selection.

1 Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
2 Committee on Genetics, University of Chicago, Chicago, IL 60637, USA.

* To whom correspondence should be addressed. E-mail: blahn{at}bsd.uchicago.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)