Response to Comments by Timpson et al. and Yu et al.

doi:10.1126/science.1143658

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Science 24 August 2007:
Vol. 317. no. 5841, p. 1036
DOI: 10.1126/science.1143658

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Technical Comments

Response to Comments by Timpson et al. and Yu et al.

Nitzan Mekel-Bobrov¹^,2 and Bruce T. Lahn¹^*

The lack of association of the abnormal spindle-like microcephalyassociated (ASPM) and Microcephalin (MCPH1) genes with brainsize or intelligence described by Timpson et al. has been reportedpreviously, including by our own group. Moreover, as in moststudies of selection, our analyses were entirely independentof phenotypic association. We also respond to the previouslypublished comment by Yu et al., which argued that ASPM has notundergone positive selection.

¹ Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
² Committee on Genetics, University of Chicago, Chicago, IL 60637, USA.

^* To whom correspondence should be addressed. E-mail: blahn{at}bsd.uchicago.edu

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