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Science 20 July 2007:
Vol. 317. no. 5836, p. 292
DOI: 10.1126/science.317.5836.292n
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The PDZ domain is a frequently occurring interaction domain in eukaryotic proteins that binds to the C-termini of target proteins. PDZ domains have been thought to cluster into functional classes, each with distinct sequence binding preferences. Using a combination of experimental data and modeling, Stiffler et al. (p. 364) predict PDZ domain-peptide interactions across the mouse proteome. Instead of observing clustering, they find that PDZ domains are evenly distributed throughout selectivity space likely to minimize cross-reactivity. The study highlights focusing on families of interaction domains as a productive approach to gain insight into protein function.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)