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Science 22 June 2007:
Vol. 316. no. 5832, p. 1698
DOI: 10.1126/science.1138410
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Technical Comments

Comment on "Tequila, a Neurotrypsin Ortholog, Regulates Long-Term Memory Formation in Drosophila"

Peter Sonderegger1* and Laszlo Patthy2

Didelot et al. (Reports, 11 August 2006, p. 851) claimed that Drosophila Tequila (Teq) and human neurotrypsin are orthologs and concluded that deficient long-term memory after Teq inactivation indicates that neurotrypsin plays its essential role for human cognitive functions through a similar mechanism. Our analyses suggest that Teq and neurotrypsin are not orthologous, leading us to question their equivalent roles in higher brain function.

1 Department of Biochemistry, University of Zurich, CH-8057 Zürich, Switzerland.
2 Institute of Enzymology, Biological Research Center, H-1113 Budapest, Hungary.

* To whom correspondence should be addressed. E-mail: Peter.Sonderegger{at}bioc.uzh.ch

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Science. ISSN 0036-8075 (print), 1095-9203 (online)