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Originally published in Science Express on 10 May 2007
Science 25 May 2007:
Vol. 316. no. 5828, pp. 1135 - 1136
DOI: 10.1126/science.1144165
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Perspectives

PHYSIOLOGY:
Proteasomes Keep the Circadian Clock Ticking

David Gatfield and Ueli Schibler

Regulated protein degradation underlies the precision of the mammalian circadian timekeeper.

D. Gatfield and U. Schibler are in the Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, CH-1211 Geneva-4, Switzerland. E-mail: david.gatfield{at}molbio.unige.ch, ueli.schibler{at}molbio.unige.ch

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation.
K. A. Lamia, U. M. Sachdeva, L. DiTacchio, E. C. Williams, J. G. Alvarez, D. F. Egan, D. S. Vasquez, H. Juguilon, S. Panda, R. J. Shaw, et al. (2009)
Science 326, 437-440
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Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock.
J.-P. Etchegaray, K. K. Machida, E. Noton, C. M. Constance, R. Dallmann, M. N. Di Napoli, J. P. DeBruyne, C. M. Lambert, E. A. Yu, S. M. Reppert, et al. (2009)
Mol. Cell. Biol. 29, 3853-3866
   Abstract »    Full Text »    PDF »


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