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Science 11 May 2007:
Vol. 316. no. 5826, pp. 840 - 842
DOI: 10.1126/science.1143336
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Perspectives

IMMUNOLOGY:
Keeping a Tight Leash on Notch

Ivan Maillard1 and Warren S. Pear2

A signaling pathway in bone marrow progenitor cells leads to T cell development unless a cellular factor intervenes and turns them toward a B cell fate.

1I. Maillard is in the Division of Hematology-Oncology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

2W. S. Pear is in the Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute and Institute of Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. E-mail: wpear{at}mail.med.upenn.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells.
S. Bai, R. Kopan, W. Zou, M. J. Hilton, C.-t. Ong, F. Long, F. P. Ross, and S. L. Teitelbaum (2008)
J. Biol. Chem. 283, 6509-6518
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Science. ISSN 0036-8075 (print), 1095-9203 (online)