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Science 20 April 2007:
Vol. 316. no. 5823, pp. 402 - 404
DOI: 10.1126/science.1140861
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Review

Male and Female Drosophila Germline Stem Cells: Two Versions of Immortality

Margaret T. Fuller1 and Allan C. Spradling2

Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite striking cellular and genetic similarities that suggest a common evolutionary origin, however, male and female GSCs also display important differences. Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production.

1 Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
2 Department of Embryology and Howard Hughes Medical Institute (HHMI), Carnegie Institution of Washington, Baltimore, MD 21218, USA.

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