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Science 20 April 2007:
Vol. 316. no. 5823, p. 397
DOI: 10.1126/science.1137543
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Review

piRNAs in the Germ Line

Haifan Lin

Small noncoding RNAs have emerged as potent regulators of gene expression at both transcriptional and posttranscriptional levels. Recently, a class of small RNAs that interact with Piwi proteins has been discovered in the mammalian germ line and Drosophila. These Piwi-interacting RNAs (piRNAs) represent a distinct small RNA pathway.

Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA.

E-mail: haifan.lin{at}yale.edu

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