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Science 13 April 2007:
Vol. 316. no. 5822, pp. 265 - 268
DOI: 10.1126/science.1139055
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Reports

Optimizing the Laser-Pulse Configuration for Coherent Raman Spectroscopy

Dmitry Pestov,1* Robert K. Murawski,1,2 Gombojav O. Ariunbold,1 Xi Wang,1 Miaochan Zhi,1 Alexei V. Sokolov,1 Vladimir A. Sautenkov,1 Yuri V. Rostovtsev,1,2 Arthur Dogariu,2 Yu Huang,2 Marlan O. Scully1,2

We introduce a hybrid technique that combines the robustness of frequency-resolved coherent anti-Stokes Raman scattering (CARS) with the advantages of time-resolved CARS spectroscopy. Instantaneous coherent broadband excitation of several characteristic molecular vibrations and the subsequent probing of these vibrations by an optimally shaped time-delayed narrowband laser pulse help to suppress the nonresonant background and to retrieve the species-specific signal. We used this technique for coherent Raman spectroscopy of sodium dipicolinate powder, which is similar to calcium dipicolinate (a marker molecule for bacterial endospores, such as Bacillus subtilis and Bacillus anthracis), and we demonstrated a rapid and highly specific detection scheme that works even in the presence of multiple scattering.

1 Institute for Quantum Studies and Departments of Physics and Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.
2 Applied Physics and Materials Science Group, Engineering Quadrangle, Princeton University, Princeton, NJ 08544, USA.

* To whom correspondence should be addressed. E-mail: dmip{at}neo.tamu.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single-shot detection of bacterial endospores via coherent Raman spectroscopy.
D. Pestov, X. Wang, G. O. Ariunbold, R. K. Murawski, V. A. Sautenkov, A. Dogariu, A. V. Sokolov, and M. O. Scully (2008)
PNAS 105, 422-427
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Science. ISSN 0036-8075 (print), 1095-9203 (online)