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Science 2 March 2007:
Vol. 315. no. 5816, pp. 1211 - 1213
DOI: 10.1126/science.315.5816.1211
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ONCOLOGY:
Recruiting the Cell's Own Guardian for Cancer Therapy

Jean Marx

Reactivating the p53 tumor suppressor has given promising results in mice, reversing and even temporarily eradicating some tumors. (Read more.)

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mass Culture and Characterization of Tumor Cells From a Naturally Occurring Invertebrate Cancer Model: Applications for Human and Animal Disease and Environmental Health.
C. Walker, S. A. Bottger, J. Mulkern, E. Jerszyk, M. Litvaitis, and M. Lesser (2009)
Biol. Bull. 216, 23-39
   Abstract »    Full Text »    PDF »
MdmX Promotes Bipolar Mitosis To Suppress Transformation and Tumorigenesis in p53-Deficient Cells and Mice.
Z. Matijasevic, H. A. Steinman, K. Hoover, and S. N. Jones (2008)
Mol. Cell. Biol. 28, 1265-1273
   Abstract »    Full Text »    PDF »
Genotoxic Stress-Induced Expression of p53 and Apoptosis in Leukemic Clam Hemocytes with Cytoplasmically Sequestered p53.
S. Bottger, E. Jerszyk, B. Low, and C. Walker (2008)
Cancer Res. 68, 777-782
   Abstract »    Full Text »    PDF »
Anti-Apoptosis Mechanisms in Malignant Gliomas.
D. S. Ziegler, A. L. Kung, and M. W. Kieran (2008)
J. Clin. Oncol. 26, 493-500
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)