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Science 19 January 2007:
Vol. 315. no. 5810, pp. 336 - 338
DOI: 10.1126/science.1138711
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Perspectives

NEUROSCIENCE:
Is More Neurogenesis Always Better?

Helen E. Scharfman1 and Rene Hen2

The clinical relevance of increasing neurogenesis in the adult mammalian brain is being questioned as increasing the number of new neurons has positive effects on some brain functions but not others.

1H. E. Scharfman is in the Departments of Pharmacology and Neurology, Columbia University, and Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, NY 10993-1195, USA. E-mail: scharfmanh{at}helenhayeshosp.org

2R. Hen is in the Departments of Pharmacology and Psychiatry and the Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

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