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Science 12 January 2007:
Vol. 315. no. 5809, p. 187
DOI: 10.1126/science.1130571
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Technical Comments

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Dieter Rosskopf,1* Alexa Bornhorst,1 Christian Rimmbach,1 Christian Schwahn,2 Alexander Kayser,1 Anne Krüger,1 Grietje Tessmann,1 Ingrid Geissler,1 Heyo K. Kroemer,1 Henry Völzke2

Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.

1 Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany.
2 Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University of Greifswald, Germany.

* To whom correspondence should be addressed. E-mail: dieter.rosskopf{at}uni-greifswald.de

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