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Science 5 January 2007:
Vol. 315. no. 5808, p. 14
DOI: 10.1126/science.315.5808.14g
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This Week in Science
MicroRNAs (miRNAs) are small ~22-nucleotide (nt) noncoding RNAs found in most eukaryotes that regulate the translation and/or stability of target RNAs. miRNAs are grouped into families that are related by their highly conserved 5' "seed" sequences that are important in defining the complementary target RNAs. The 3' sequences are generally less conserved within families, which has raised questions about their functional significance. Even so, 3' sequences can be very highly conserved (even identical) across species for individual miRNAs, which suggests the presence of powerful selective constrains. Hwang et al. (p. 97) now show that human miR-29b is localized to the nucleus and that this localization is driven by a 6-nt sequence in the 3' half of the molecule. The authors raise the intriguing possibility that miR-29b might regulate the transcription or splicing of target transcripts.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
