G Protein Signaling in Yeast: New Components, New Connections, New Compartments
Janna E. Slessareva and
Henrik G. Dohlman*
Signaling by cell surface receptors and heterotrimeric guanine
nucleotide–binding proteins (G proteins) is one of the
most exhaustively studied processes in the cell but remains
a major focus of molecular pharmacology research. The pheromone-response
system in yeast (see the Connections Map at
Science's Signal
Transduction Knowledge Environment) has provided numerous major
advances in our understanding of G protein signaling and regulation.
However, the basic features of this prototypical pathway have
remained largely unchanged since the mid-1990s. New tools available
in yeast are beginning to uncover new pathway components and
interactions and have revealed signaling in unexpected locations
within the cell.
* To whom correspondence should be addressed. E-mail: hdohlman{at}med.unc.edu
