Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 November 2006:
Vol. 314. no. 5803, pp. 1292 - 1295
DOI: 10.1126/science.1133953
Prev | Table of Contents | Next

Reports

Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila

Nicholas J. Brideau,* Heather A. Flores,* Jun Wang,* Shamoni Maheshwari, Xu Wang, Daniel A. Barbash{dagger}

The Dobzhansky-Muller model proposes that hybrid incompatibilities are caused by the interaction between genes that have functionally diverged in the respective hybridizing species. Here, we show that Lethal hybrid rescue (Lhr) has functionally diverged in Drosophila simulans and interacts with Hybrid male rescue (Hmr), which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males. LHR localizes to heterochromatic regions of the genome and has diverged extensively in sequence between these species in a manner consistent with positive selection. Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: dab87{at}cornell.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Imprinting of the Y Chromosome Influences Dosage Compensation in roX1 roX2 Drosophila melanogaster.
D. U. Menon and V. H. Meller (2009)
Genetics 183, 811-820
   Abstract »    Full Text »    PDF »
Recent Progress in Plant Reproduction Research: The Story of the Male Gametophyte through to Successful Fertilization.
G. Suzuki (2009)
Plant Cell Physiol. 50, 1857-1864
   Abstract »    Full Text »    PDF »
Colloquium Papers: Genetics and ecological speciation.
D. Schluter and G. L. Conte (2009)
PNAS 106, 9955-9962
   Abstract »    Full Text »    PDF »
Reduced Fertility of Drosophila melanogaster Hybrid male rescue (Hmr) Mutant Females Is Partially Complemented by Hmr Orthologs From Sibling Species.
S. Aruna, H. A. Flores, and D. A. Barbash (2009)
Genetics 181, 1437-1450
   Abstract »    Full Text »    PDF »
Genetics and Lineage-Specific Evolution of a Lethal Hybrid Incompatibility Between Drosophila mauritiana and Its Sibling Species.
M. V. Cattani and D. C. Presgraves (2009)
Genetics 181, 1545-1555
   Abstract »    Full Text »    PDF »
Evolution of the Drosophila Nuclear Pore Complex Results in Multiple Hybrid Incompatibilities.
S. Tang and D. C. Presgraves (2009)
Science 323, 779-782
   Abstract »    Full Text »    PDF »
Divergent Evolution of Duplicate Genes Leads to Genetic Incompatibilities Within A. thaliana.
D. Bikard, D. Patel, C. Le Mette, V. Giorgi, C. Camilleri, M. J. Bennett, and O. Loudet (2009)
Science 323, 623-626
   Abstract »    Full Text »    PDF »
A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase.
O. Mihola, Z. Trachtulec, C. Vlcek, J. C. Schimenti, and J. Forejt (2009)
Science 323, 373-375
   Abstract »    Full Text »    PDF »
A Single Gene Causes Both Male Sterility and Segregation Distortion in Drosophila Hybrids.
N. Phadnis and H. A. Orr (2009)
Science 323, 376-379
   Abstract »    Full Text »    PDF »
Recurrent Positive Selection of the Drosophila Hybrid Incompatibility Gene Hmr.
S. Maheshwari, J. Wang, and D. A. Barbash (2008)
Mol. Biol. Evol. 25, 2421-2430
   Abstract »    Full Text »    PDF »
The strength and genetic basis of reproductive isolating barriers in flowering plants.
D. B Lowry, J. L Modliszewski, K. M Wright, C. A Wu, and J. H Willis (2008)
Phil Trans R Soc B 363, 3009-3021
   Abstract »    Full Text »    PDF »
A Complex Genetic Basis to X-Linked Hybrid Male Sterility Between Two Species of House Mice.
J. M. Good, M. D. Dean, and M. W. Nachman (2008)
Genetics 179, 2213-2228
   Abstract »    Full Text »    PDF »
Accelerated Mitochondrial Evolution and "Darwin's Corollary": Asymmetric Viability of Reciprocal F1 Hybrids in Centrarchid Fishes.
D. I. Bolnick, M. Turelli, H. Lopez-Fernandez, P. C. Wainwright, and T. J. Near (2008)
Genetics 178, 1037-1048
   Abstract »    Full Text »    PDF »
Significant Variation for Fitness Impacts of ETS Loci in Hybrids between Populations of Tigriopus californicus.
C. S. Willett (2008)
J. Hered. 99, 56-65
   Abstract »    Full Text »    PDF »
Cytonuclear Genic Incompatibilities Cause Increased Mortality in Male F2 Hybrids of Nasonia giraulti and N. vitripennis.
O. Niehuis, A. K. Judson, and J. Gadau (2008)
Genetics 178, 413-426
   Abstract »    Full Text »    PDF »
Developmental and Cell Cycle Progression Defects in Drosophila Hybrid Males.
B. J. Bolkan, R. Booker, M. L. Goldberg, and D. A. Barbash (2007)
Genetics 177, 2233-2241
   Abstract »    Full Text »    PDF »
Drosophila Biology in the Genomic Age.
T. A. Markow and P. M. O'Grady (2007)
Genetics 177, 1269-1276
   Abstract »    Full Text »    PDF »
Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila.
M. A. Rodriguez, D. Vermaak, J. J. Bayes, and H. S. Malik (2007)
PNAS 104, 15412-15417
   Abstract »    Full Text »    PDF »
Asymmetric Postmating Isolation: Darwin's Corollary to Haldane's Rule.
M. Turelli and L. C. Moyle (2007)
Genetics 176, 1059-1088
   Abstract »    Full Text »    PDF »
Nup96-Dependent Hybrid Lethality Occurs in a Subset of Species From the simulans Clade of Drosophila.
D. A. Barbash (2007)
Genetics 176, 543-552
   Abstract »    Full Text »    PDF »
Speciation in Drosophila: From Phenotypes to Molecules.
H. A. Orr, J. Masly, and N. Phadnis (2007)
J. Hered. 98, 103-110
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)