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Science 24 November 2006:
Vol. 314. no. 5803, p. 1213
DOI: 10.1126/science.314.5803.1213h
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This Week in Science

So-called Dobzhansky-Muller genes interact to produce hybrid sterility. Brideau et al. (p. 1292; see the news story by Pennisi) have identified, cloned, and characterized the Lethal hybrid rescue (Lhr) gene in Drosophila simulans, which encodes a protein that localizes to heterochromatic regions of the genome. The proteins encoded by Lhr and Hybrid male rescue (Hmr) form a pair of Dobzhansky-Muller hybrid incompatibility genes, which appear to cause hybrid lethality only in a hybrid genetic background.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)