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Science 17 November 2006:
Vol. 314. no. 5802, p. 1045
DOI: 10.1126/science.314.5802.1045h
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N-linked protein glycosylation is the most frequent posttranslational modification of proteins in eukaryotic cells, and a functionally homologous process also occurs in bacteria. The key component of this bacterial system is PglB, an oligosaccharylotransferase that catalyzes the transfer of the oligosaccharide to selected asparagine residues within a protein. Kowarik et al. (p. 1148) show that, unlike the eukaryotic system, the bacterial oligosaccharyl transferase can act independently of the protein translocation machinery and can glycosylate fully folded proteins in vitro.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)