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Sea Urchin Genome Sequencing Consortium
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Research ArticlesThe Genome of the Sea Urchin Strongylocentrotus purpuratusSea Urchin Genome Sequencing Consortium: 
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
1 Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
2 Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. 3 Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. 4 National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA. 5 Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy. 6 Department of Biology, Boston College, Chestnut Hill, MA 02467, USA. 7 Department of Biology, Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada, V8W 3N5. 8 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA. 9 Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute–Frederick, Frederick, MD 21702, USA. 10 School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK. 11 Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, 15213, USA. 12 Department Molecular, Cellular and Developmental Biology and the Marine Science Institute, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA. 13 Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA. 14 Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. 15 Departments of Biochemistry and Molecular Biology, University of Texas, M.D.Anderson Cancer Center, Houston, TX, 77030, USA. 16 Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. 17 Department of Biology, Duke University, Durham, NC 27708, USA. 18 Department of Biology, Wheaton College, Norton, MA 02766, USA. 19 Stowers Institute for Medical Research, Kansas City, MO 64110, USA. 20 Department of Microbiology, Kansas University Medical Center, Kansas City, KS 66160, USA. 21 Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, M4N 3M5. 22 Department of Biological Sciences, George Washington University, Washington, DC 20052, USA. 23 Royal Swedish Academy of Sciences, Kristineberg Marine Research Station, Fiskebackskil, 450 34, Sweden. 24 Marine Biology, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093–0202, USA. 25 Department of Molecular and Cellular Biology and Biochemistry, Brown University Providence, RI 02912, USA. 26 Department of Biology and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA. 27 Department of Animal Science, Texas A&M University, College Station, TX 77843, USA. 28 National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894, USA. 29 Department of Ecology, Evolution, and Marine Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA. 30 Penn Genomics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. 31 Evolution and Development Group, Max-Planck Institut fuer Molekulare Genetik, 14195 Berlin, Germany. 32 Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK. 33 Center for Cancer Research, MIT, Cambridge, MA 02139, USA. 34 Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720–3200, USA. 35 Biology Department, California Polytechnic State University, San Luis Obispo, CA 93407, USA. 36 Université Pierre et Marie Curie-Paris6, UMR 7150, Equipe Cycle Cellulaire et Développement, Station Biologique de Roscoff, 29682 Roscoff Cedex, France. 37 CNRS, UMR 7150, Station Biologique de Roscoff, 29682 Roscoff Cedex, France. 38 CNRS, UMR7628, Banyuls-sur-Mer, F-66650, France. 39 Université Pierre et Marie Curie-Paris 6, UMR7628, Banyuls-sur-Mer, F-66650, France. 40 Center for Bioinformatics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. 41 Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. 42 Tethys Research, LLC, 2115 Union Street, Bangor, Maine 04401, USA. 43 Department of Molecular, Cellular, and Developmental Biology, University of California, Berkeley, Berkeley, CA 94720, USA. 44 Center for Computational Molecular Biology, and Computer Science Department, Brown University, Providence, RI 02912, USA. 45 Genome Research Facility, National Aeronautics and Space Administration, Ames Research Center, Moffet Field, CA 94035, USA. 46 Systemix Institute, Cupertino, CA 95014, USA. 47 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada, V5A 1S6. 48 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada, V5A 1S6. 49 Department of Biology, Center for Cancer Research, MIT, Cambridge, MA 02139, USA. 50 Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089–0740, USA. 51 Department of Biology, University of Central Florida, Orlando, FL 32816–2368, USA. 52 Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. 53 Center for Computational Regulatory Genomics, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA. 54 Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. 55 Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, V5Z 4E6. 56 Department of Immunology, University of Toronto, Toronto, Ontario, Canada, M4N 3M5. 57 Department of Biology and the Institute of Systems Research, University of Maryland, College Park, MD 20742, USA. 58 Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. 59 Department of Biological Sciences, Macquarie University, Sydney NSW 2109, Australia. 60 Center of Marine Biotechnology, UMBI, Columbus Center, Baltimore, MD 21202, USA. 61 Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. 62 Department of Biology, University of Victoria, Victoria, BC, Canada, V8W 2Y2. 63 Department of Neuroscience, Uppsala University, Uppsala, Sweden. 64 Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Development, NIH, Bethesda, MD 20895, USA. 65 Developmental Unit, EMBL, 69117 Heidelberg, Germany. 66 Computational Unit, EMBL, 69117 Heidelberg, Germany. 67 Biotechnology Institute, Universidad Nacional Autónoma de Mexico (UNAM), Cuernavaca, Morelos, Mexico 62250. 68 Department of Cellular and Developmental Biology "Alberto Monroy," University of Palermo, 90146 Palermo, Italy. 69 Laboratoire de Biologie du Développement (UMR 7009), CNRS and Université Pierre et Marie Curie (Paris 6), Observatoire Océanologique, 06230 Villefranche-sur-Mer, France. 70 Department of Biology, University of Patras, Patras, Greece. 71 Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. 72 Departament de Genetica, Universitat de Barcelona, 08028–Barcelona, Spain. 73 Institució Catalana de Recerca i Estudis Avancats (ICREA), Barcelona, Spain. 74 Institut Jacques Monod, CNR-UMR 7592, 75005 Paris, France. 75 Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare "Alberto Monroy," 90146 Palermo, Italy. 76 Department of Zoology, University of Hawaii at Manoa, Honolulu, HI 96822, USA. 77 Department of Biology, University of South Florida, Tampa, FL 33618, USA. 78 Razavi-Newman Center for Bioinformatics, Salk Institute for Biological Studies, La Jolla, CA 92186, USA.
* To whom correspondence should be addressed. E-mail: gwstock{at}bcm.tmc.edu
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Present address: Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA. Science. ISSN 0036-8075 (print), 1095-9203 (online)
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