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Science 27 October 2006:
Vol. 314. no. 5799, pp. 603 - 605
DOI: 10.1126/science.1132692
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Perspectives

BIOCHEMISTRY:
Directing Biosynthesis

Michael A. Fischbach1 and Christopher T. Walsh2

Genetic engineering is revealing biosynthetic pathways for synthesis of small molecules and avenues toward cheaper syntheses, potentially providing access to better drugs.

1M. A. Fischbach is in the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, and in the HHMI and the Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

2C. T. Walsh is in the Department of Biological Chemisty and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. E-mail: christopher_walsh{at}hms.harvard.edu

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