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Science 13 October 2006:
Vol. 314. no. 5797, p. 220
DOI: 10.1126/science.314.5797.220g
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This Week in Science

Knowing which genes are recurrently mutated in cancer cells helps illuminate the molecular pathways that underlie tumorigenesis. In a pilot study, Sjöblom et al. (p. 268; published online 7 September; see the cover and the 8 September news story by Kaiser) have sequenced 13,000 protein-coding genes in human breast and colorectal cancers and developed methods for distinguishing harmless sequence changes from causal mutations. Almost 200 candidate cancer genes (CAN genes) were mutated at significant frequency, many of which had not been previously implicated in tumorigenesis. Notably, there was little overlap of CAN genes mutated in breast and colorectal cancers, nor was there substantial overlap in different tumor specimens derived from the same tissue.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)