Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 October 2006:
Vol. 314. no. 5796, p. 95
DOI: 10.1126/science.1130994
Prev | Table of Contents | Next

Brevia

Generation of Simian-Tropic HIV-1 by Restriction Factor Evasion

Theodora Hatziioannou,1 Michael Princiotta,2 Michael Piatak, Jr.,2 Fang Yuan,2 Fengwen Zhang,1 Jeffrey D. Lifson,2 Paul D. Bieniasz1*

Because HIV-1 does not infect most nonhuman primates, animal modeling of human HIV infection and AIDS has primarily consisted of experimentally infecting macaques with related simian immunodeficiency viruses (SIVMAC). However, the usefulness of such models is limited by the substantial divergence between SIVMAC and HIV-1. We derived an HIV-1-based virus that includes only small portions of SIVMAC yet replicates robustly in both transformed and primary rhesus macaque T cells. Derivation of simian-tropic HIV-1 (stHIV-1) has important implications for understanding primate lentivirus zoonosis and should allow the development of improved animal models for studies of AIDS and the evaluation of vaccines and treatments.

1 Aaron Diamond AIDS Research Center and Rockefeller University, 455 First Avenue, New York, NY 10016, USA.
2 AIDS Vaccine Program, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, MD 21702, USA.

* To whom correspondence should be addressed. E-mail: pbienias{at}adarc.org

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of a Human Immunodeficiency Virus Type 1-Based Lentiviral Vector That Allows Efficient Transduction of both Human and Rhesus Blood Cells.
N. Uchida, K. N. Washington, J. Hayakawa, M. M. Hsieh, A. C. Bonifacino, A. E. Krouse, M. E. Metzger, R. E. Donahue, and J. F. Tisdale (2009)
J. Virol. 83, 9854-9862
   Abstract »    Full Text »    PDF »
A macaque model of HIV-1 infection.
T. Hatziioannou, Z. Ambrose, N. P. Y. Chung, M. Piatak Jr., F. Yuan, C. M. Trubey, V. Coalter, R. Kiser, D. Schneider, J. Smedley, et al. (2009)
PNAS 106, 4425-4429
   Abstract »    Full Text »    PDF »
APOBEC proteins and intrinsic resistance to HIV-1 infection.
M. H Malim (2009)
Phil Trans R Soc B 364, 675-687
   Abstract »    Full Text »    PDF »
Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5{alpha} proteins including human TRIM5{alpha}.
A. Wood, B. L. J. Webb, B. Bartosch, T. Schaller, Y. Takeuchi, and G. J. Towers (2009)
J. Gen. Virol. 90, 702-709
   Abstract »    Full Text »    PDF »
Identification of Postentry Restrictions to Mason-Pfizer Monkey Virus Infection in New World Monkey Cells.
W. E. Diehl, E. Stansell, S. M. Kaiser, M. Emerman, and E. Hunter (2008)
J. Virol. 82, 11140-11151
   Abstract »    Full Text »    PDF »
Primate Lentivirus Capsid Sensitivity to TRIM5 Proteins.
Z. Kratovac, C. A. Virgen, F. Bibollet-Ruche, B. H. Hahn, P. D. Bieniasz, and T. Hatziioannou (2008)
J. Virol. 82, 6772-6777
   Abstract »    Full Text »    PDF »
Antiretroviral Activity and Vif Sensitivity of Rhesus Macaque APOBEC3 Proteins.
C. A. Virgen and T. Hatziioannou (2007)
J. Virol. 81, 13932-13937
   Abstract »    Full Text »    PDF »
Novel TRIM5 Isoforms Expressed by Macaca nemestrina.
G. Brennan, Y. Kozyrev, T. Kodama, and S.-L. Hu (2007)
J. Virol. 81, 12210-12217
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Derivative with 7% Simian Immunodeficiency Virus Genetic Content Is Able To Establish Infections in Pig-Tailed Macaques.
T. Igarashi, R. Iyengar, R. A. Byrum, A. Buckler-White, R. L. Dewar, C. E. Buckler, H. C. Lane, K. Kamada, A. Adachi, and M. A. Martin (2007)
J. Virol. 81, 11549-11552
   Abstract »    Full Text »    PDF »
Alpha Interferon Enhances TRIM5{alpha}-Mediated Antiviral Activities in Human and Rhesus Monkey Cells.
R. Sakuma, A. A. Mael, and Y. Ikeda (2007)
J. Virol. 81, 10201-10206
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)