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Science 6 October 2006:
Vol. 314. no. 5796, pp. 65 - 66
DOI: 10.1126/science.1133987
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Perspectives

CHEMISTRY:
Mass Spectrometry: Bottom-Up or Top-Down?

Brian T. Chait

A novel approach to mass spectrometry involving fragmentation of intact proteins in the gas phase promises to greatly improve our ability to determine protein modifications.

The author is in the Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, New York, NY 10021, USA. E-mail: chait{at}rockefeller.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Unraveling Molecular Complexity of Phosphorylated Human Cardiac Troponin I by Top Down Electron Capture Dissociation/Electron Transfer Dissociation Mass Spectrometry.
V. Zabrouskov, Y. Ge, J. Schwartz, and J. W. Walker (2008)
Mol. Cell. Proteomics 7, 1838-1849
   Abstract »    Full Text »    PDF »
A review of algorithmic techniques for disulfide-bond determination.
R. Singh (2008)
Brief Funct Genomic Proteomic
   Abstract »    Full Text »    PDF »
Mass spectrometry is only one piece of the puzzle in clinical proteomics.
J. N. McGuire, J. Overgaard, and F. Pociot (2008)
Brief Funct Genomic Proteomic
   Abstract »    Full Text »    PDF »
Certain and Progressive Methylation of Histone H4 at Lysine 20 during the Cell Cycle.
J. J. Pesavento, H. Yang, N. L. Kelleher, and C. A. Mizzen (2008)
Mol. Cell. Biol. 28, 468-486
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)